The first references to this diet appeared in medical literature in 1864 (28)
Due to side effects that may result with intravenous use, the government of the Philippines recommends against such use

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Karthikeyan K, Bai BR, Devaraj SN (2009) Efficacy of grape seed proanthocyanidins on cardioprotection during isoproterenol-induced myocardial injury in rats