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In the red blood cell, the reduced form of glutathione is vital in maintaining hemoglobin in a reduced state and hence protecting the cells from oxidative damage

The alkyl radical in the presence of oxygen is converted to peroxyl radicals which facilitate the long-term damage by continually regenerating themselves through hydrogen abstraction from the nearby biomolecules and forming the hydroperoxides as the byproduct (Fig

For topical formulations, concentrations of 0.1 to 0.3 percent are used, with efficacy detectable from as low as 0.01 percent

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