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The FDA Adverse Event Reporting System (FAERS) contains reports of various gastrointestinal complications, though these reports have significant limitationsincluding underreporting, lack of denominator data, and inability to establish causality

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Experimental models report healing improvements within 14 to 21 days through increased cellular activity and improved nutrient delivery to injured sites

This shift creates opportunities for API manufacturers offering dual-sourcing or regional manufacturing, enabling them to command premium pricing, lock in long-term offtake agreements, and build more resilient customer relationships