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Repeated insults can result in eventual fibrosis of the pancreas and a multitude of secondary sequelae, which may lead to the loss of pancreatic function [1]

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Intracellular lactate/pyruvate ( a ), 2-hydroxybutyrate/2-ketobutyrate (2HB/2KB) ( b ), 3-hydroxybutyrate/acetoacetate (3HB/AcAc) ( c ), glycerol 3-phosphate/dihydroxyacetone phosphate (Gro3P/DHAP) ( d ), C16:1/C16:0 ( e ) and AMP/ATP ( f ) ratios measured in HeLa cells expressing Ec STH and mito Ec STH