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Back to Journals Drug Design, Development and Therapy Volume 19 The Clinical Application of GLP-1RAs and GLP-1/GIP Dual Receptor Agonists Based on Pharmacological Mechanisms: A Review Authors Liu Z, Yu S, Jin X, Sheng L, YanMu MR, Gao J, Lu J, Lei T Received 11 August 2025 Accepted for publication 15 November 2025 Published 22 November 2025 Volume 2025:19 Pages 1038310409 DOI Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Professor Anastasios Lymperopoulos Zhao Liu, 1 Shanshan Yu, 1 Xinyan Jin, 1 Luguang Sheng, 2 Mai Re YanMu, 1 Jie Gao, 1 Jun Lu, 1 Tao Lei 1 1 Department of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, Peoples Republic of China
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Abbreviations 3-PG: 3-phosphoglycerate ADI: arginine deaminase ALL: acute lymphoblastic leukemia AMPK: AMP-activated protein kinase ARG1: arginase 1 ARG2: arginase 2 ASS1: arginine-succinate synthase 1 ASNS: asparagine synthetase BMT: black mesoporous titanium dioxide CRC: colorectal cancer DOX: doxorubicin EAA: essential amino acid EPR: enhanced permeability and retention FDA: Food and Drug Administration GCN2: general control nonderepressible 2 GLDC: glycine decarboxylase GLS: glutaminase GOD: glucose oxidase GS: glutamine synthetase GSH: glutathione GT: gas therapy H 2 O 2 : hydrogen peroxide H 2 S: hydrogen sulfide HA: hyaluronic acid HCC: hepatocellular carcinoma ICB: immune checkpoint blockade MDSCs: myeloid-derived suppressor cells MMA: monomethylarginine MMPs: matrix metalloproteinases mPEG-ICG: PEGylated indocyanine green MOFs: metal-organic frameworks MR: methionine restriction mTORC1: mechanistic target of rapamycin complex 1 NADPH: nicotinamide adenine dinucleotide phosphate NEAA: non-essential amino acid NIR: near-infrared NO: nitric oxide NP: nanoparticles OAA: oxaloacetate OXPHOS: oxidative phosphorylation PD-1: programmed cell death protein 1 PDAC: pancreatic ductal adenocarcinoma PD-L1: programmed cell death ligand 1 PHGDH: phosphoglycerate dehydrogenase PK: pharmacokinetics PKM2: pyruvate kinase M2 PLGA: polylactic acid glycolic acid PLT: platelet PRMTs: protein arginine methyltransferases PSAT1: phosphoserine aminotransferase 1 PSPH: phosphoserine phosphatase RCC: renal cell cancer RNS: reactive nitrogen species ROS: reactive oxygen species RP2D: recommended phase 2 dose SAM: S-adenosylmethionine SHMT: serine hydroxymethyltransferase SSP: serine synthesis pathway TAMs: tumor-associated macrophages TCA: tricarboxylic acid TME: tumor microenvironment US: ultrasound VISTA: V-domain Ig suppressor of T cell activation -KG: -ketoglutarate -MT: -methyl-DL-tryptophan References Wang D, Wan X
