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The metabolic stress caused by long-term lipid dysregulation may overwhelm the ER with the folding demands of lipid-metabolizing enzymes, worsening misfolded protein buildup, and activating the UPR
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No differences were observed in the liver content of NADPH (control: 0.25 0.04 and pravastatin: 0.25 0.05 nmol/mg protein) and NADP + (control: 0.08 0.00 and pravastatin: 0.06 0.01 nmol/mg protein) of both groups of mice
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