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Cochrane Database Syst Rev

The observed adverse effects were associated with thiol antioxidant depletion and activation of Nrf2 signalling, indicating an adaptive response to redox imbalance

Shank3B knockout (Shank3B /) mice exhibit hypersensitivity to tactile stimuli, which correlates closely with increased spontaneous discharge and stimulus-evoked activity in pyramidal neurons, as well as reduced activity in interneurons, within the primary somatosensory cortex (vS1)