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The human albumin variants were expressed in a serum-free transient Expi293 expression system, and all were secreted at comparable quantities to that of WT albumin (2546 mg/L) (Supplementary Fig

8 AlvarezL.GarcaM.RodrguezS.FernndezB.PereiroR.Sanz-MedelA.et al

It downregulates the gene and protein expression of COX1, 5-LOX, 12-LOX, and 15-LOX in the arachidonic acid pathway, restores the levels of abnormal metabolites such as PGE2, PGD2, LTB4, 12-HETE, 15-HETE, PGF2, and 8-iso-PGF2 in PAH models, inhibits abnormal proliferation of PASMCs, and reverses pulmonary vascular remodeling (Song et al., 2022)

Moreover, only minor differences in the plasma concentration of QMP and QMP/LX were detected over time (Fig