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Quantitative real-time polymerase chain reaction (qRT-PCR) for target gene expression was performed using the SensiFAST SYBR No-ROX Kit (Bioline)

First, FFAs create a high-oxidative state that triggers the release of calcium ions (Ca + ) from the ER, which increases intracellular Ca + concentrations and retroactively activates various digestive enzymes, including trypsin ( Clinical studies have indicated that patients with hypertriglyceridemia-induced AP often experience more severe abdominal pain, higher fever, and markedly increased levels of inflammatory markers such as C-reactive protein (CRP) and interleukin-6 (IL-6) ( Another important aspect of the link between hypertriglyceridemia and necrotizing pancreatitis is the role of genetic factors

Change in body weight was calculated, and safety data were also analyzed

While these early signs are exciting, we dont have enough proof yet