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Dual modifications, such as 2,4- and 2,5-sugar modifications, have been employed in the development of siRNA therapeutics to further expand the potential of ribose modifications
These observations indicate that GSH-dependent thiol modifications regulate necroptosis at multiple hierarchical levels, from upstream checkpoint proteases to terminal membrane-disrupting effectors
A patient who cant swallow a capsule, for example, may require a liquid version of a drug
Diabetes 49:677683 Schmitz-Peiffer C (2002) Protein kinase C and lipid-induced insulin resistance in skeletal muscle
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