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SHMT2 also exerts influence on tumor cells ability to migrate and proliferate, supporting metabolic adaptations through Akt2 and n-Myc activation in human neuroblastoma cells [121], or hypoxia inducible factor 1 (HIF-1) activation in human gastric cancer cells [122]

Plasmid construction and siRNA Plvsin-GGCT-eGFP expression plasmid was constructed by inserting the full-length GGCT sequence amplified from human cDNA and ligated into the Plvsin-eGFP vectors

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This suggests that the method of administration may influence the experience of fatigue, although more research is needed to confirm this