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However, controversy still exists as to whether it is best to therapeutically promote or inhibit GIP action for beneficial effects on glycemic control and body weight [[929], [930], [931]] as both GIPR agonists [932] and antagonists [933,934] have decreased body weight in preclinical studies as individual treatments, but also to induce synergistic body weight loss when combined with GLP-1R agonists

Investors are also eyeing Pfizer Inc.s experimental danuglipron after a mid-stage study yielded positive results

This may be due to impaired lactate clearance resulting in higher lactate blood levels