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Mechanism of Action PT-141 works by binding to melanocortin receptors (MC-3 and MC-4) in the central nervous system, particularly within the hypothalamus

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sciencedirect.com/science/articl Obesity pharmacotherapy from the @TheAACE diabetes algorithm: GLP1/GIP and GLP1 RAs produce ~1020% weight loss with A1c reduction, while older agents like phentermine, orlistat, and naltrexone/bupropion have less efficacy and safety tradeoffs