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Intranasal delivery using a lung-tropic adeno-associated virus 9 vector to prime and chemokine pull (CXCL11) effectively induced SARS-CoV-2-specific lung-resident T cells and offered better protection against SARS-CoV-2 in mice [168] (Table 2)

In contrast, studies involving conditions such as schizophrenia, osteoarthritis, migraine, and functional gastrointestinal disorders were grouped under Non-metabolic chronic conditions, due to their distinct primary pathophysiological pathways, which do not centrally involve metabolic dysregulation

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Accordingly, its long-term neurotrophic and analgesic activity has been confirmed in animal models of chronic inflammatory and neuropathic pain and in clinical studies in patients with peripheral neuropathies