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Nowadays, chronic vitamin D supplementation has become rather controversial since several large intervention trials have not shown significant benefits in the elderly population with cardiovascular diseases (recently reviewed in Ref

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doi: 10.3389/fimmu.2026.1845654 Received 02 April 2026 Revised 07 April 2026 Accepted 21 April 2026 Published 11 May 2026 Volume 17 - 2026 Edited by Venkata Ramireddy Narala, Yogi Vemana University, India Reviewed by Farrah Kheradmand, Baylor College of Medicine, United States Homayon Ghiasi, Cedars Sinai Medical Center, United States Updates Copyright 2026 Cain, Hurrell, Shen, Speliakos and Akbari