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The amount of oral intake needed to achieve gastric and intestinal fullness and signal satiety to the brain through the gut-brain axis can overwhelm the evolutionarily determined metabolic capacity of peripheral organs such as liver, pancreas, fat tissue, and muscles

Isotopic tracing with 15N-labeled glutamine revealed that 57% of ammonium is recycled via GDH-mediated reductive amination, generating 15N-labeled amino acids (excluding proline and glutathione, which are synthesized directly from glutamate) (83)

Pedram A, Razandi M, O'Mahony F, Harvey H, Harvey BJ, Levin ER