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Research shows that the aloe vera history goes back over 4,000 years, when Sumerian clay tablets from 2100 BCE mentioned its use as a medicine

Published microarray and RNA-seq studies have documented effects on growth hormone (GH1), pituitary-specific transcription factor Pit-1, ghrelin O-acyltransferase (GOAT), and downstream IGF-1 axis genes

The absence of many reports may reflect limited systematic monitoring rather than an absence of risk

Makary said in a statement on Friday that the agency will "use all available compliance and enforcement tools within its authorities to address unsubstantiated claims and associated public health concerns." HHS, which oversees the FDA, was not immediately available for comment