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Preliminary data point toward beneficial effects of GIP agonism, as reported in findings from the SURPASS program that tirzepatide reduced UACR and slowed down eGFR declined in comparison with both placebo (53) and comparator drugs including insulin glargine (74, 75)

This is why many physicians view tirzepatide as a long-term or indefinite treatment rather than a short course

This is administered by spraying it inside your mouth, and letting it dissolve and absorb through the tiny capillaries

For patients with NASH (suspected or proven by biopsy), the target of weight loss is even higher (7 to 10% of the initial body weight)