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Under oxidizing conditions, two monomeric redox states (red, ox1) could be distinguished, as the monomer migrates as a double band in GSAAT(WT) proteins and points to an independent intra-molecular redox modification

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Therefore, the beneficial effects of ROS are achievable within physiological levels and deviation from redox window (as oxidative or reductive stresses) [29] will be associated with different pathologies including neurodegenerative diseases [30] diabetes [31] cardiovascular disease and atherosclerosis [32] rheumatoid arthritis [33] respiratory disease [34] carcinogenesis [35] ageing [36] female reproductive disease, pregnancy complications and recurrent pregnancy loss [37]