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Use of Tesamorelin outside of approved clinical indications is not authorized in many jurisdictions

Semaglutide weight loss injections are generally well-tolerated, with mild side effects, especially when compared to the health risks associated with obesity or being overweight

29 Clinical trials assessing the efficacy of LOLA showed that it is at least comparable (sometimes superior) to other interventions (such as lactulose or oral antibiotics), in addition to being well-tolerated and associated with improvement in quality of life

Modelling and simulation of efficacy and exposure data from the phase 3a STEP (subcutaneous semaglutide 2 -4 mg) and OASIS (oral semaglutide) programmes suggested that increasing the dose of semaglutide might provide further bodyweight reduction and health benefits without jeopardising safety or significantly increasing the risk of adverse events