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Furthermore, unpublished studies often lacked sufficient methodological detail for quality appraisal, outcome data, and long-term follow-up, and the absence of peer review made it difficult to appraise internal validity in a standardised way
At the cellular level, key elements play a pivotal role in promoting skin elasticity, combating oxidative stress, and enhancing overall well-being
However, it was not possible to obtain the initial results again, and this compound was also excluded from clinical trials ( in vitro , so its activity may be due to other mechanisms of action (Maples et al., 2001)