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Recent evidence shows that HSP70s are involved into transmembrane protein translocation via entropic pulling (Rukes et al., 2024), into the protection of damaged muscle fibers via calcium reuptake from the sarcoplasm to the reticulum (Barfoot et al., 2025), and into the regulation of enzymes that mark proteins with ultraviolet-dependent damage (Zeng et al., 2025)

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(20) This figure illustrates the mechanisms that can be used to effectively administer BPC-157