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Although these drugs targeting GM dysbiosis hold significant potential in the prevention and treatment of liver diseases (See Table 5), several limitations and challenges remain

GES may be considered for compassionate treatment in patients with refractory symptoms, particularly nausea and vomiting

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AOD-9604: measurable fat loss within 3-4 weeks, visible changes by weeks 6-8 CJC-1295 + Ipamorelin: noticeable body composition changes at 4-6 weeks Semaglutide: rapid appetite suppression within days, significant weight loss over months (1-2 lbs/week, peak at 60-68 weeks) MOTS-c: subtle improvements over 6-8 weeks Focus on 8-12 week evaluation periods