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The second benefit of the bidirectional two-sample MR design is that it permits causal inference that is free from the problems of reverse causality and other confounding variables that can arise in observational studies

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The antacids represent one of the most prescribed categories of drugs worldwide: the interference with thyroxine bioavailability has been described for proton pump inhibitors and calcium carbonate ( in vitro : indeed, it appears to bind thyroxine in a dose-dependent manner when medium pH is two