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These medicines are highly effective and are helping many people, Ariaee says

Specifically, the FDA has approved semaglutide for adults who are clinically obese (BMI of 30 or higher) or overweight (BMI of 27 or higher) when accompanied by at least one weight-related health condition, such as hypertension, hyperlipidemia, cardiovascular disease, prediabetes, or obstructive sleep apnea

Indications Indications Indicated as an adjunct to diet and physical activity to improve glycemic control in adults with type 2 diabetes mellitus

Gastrointestinal effects are the most frequently reported adverse reactions according to the SmPC, with specific frequencies from clinical trials including nausea (approximately 44%), diarrhoea (30%), vomiting (24%), and constipation (24%)