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Single-receptor GLP-1 agonists engage only the GLP-1 receptor, while Zepbound, as tirzepatide, adds the GIP receptor for a second incretin mechanism

Ferroptosis does not require a specific pro-death signaling pathway but is triggered spontaneously when the protection of cellular membrane phospholipids from peroxidation by the metabolites and enzymes, including cysteine and glutathione peroxidase 4 (GPX4), are weakened [228, 229]