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Additionally, our molecular experiments confirmed that chemotherapy drugs increase the expression levels of intracellular GSH and antioxidant enzymes, leading to chemotherapy resistance during neoadjuvant chemotherapy

More globally, analysis of GPX4 protein expression levels performed in up to forty different cancers show that besides AML, GPX4 is also elevated in most hematological malignancies including Acute Lymphoblastic Leukemia (ALL), Multiple Myeloma (MM) and Non-Hodgkin's Lymphoma (NHL) [39]

Consistency matters more than intensity, since steady glutathione levels are what sustain the brightening effect over time

Kaparov, P., Vakov, E., Fouskov, E., Mask, J