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As a theoretical possibility, an increase in endogenous 6-OHDA would trigger the formation of Lewy bodies in dopaminergic neurons and eventually lead to their degeneration

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This complication has been assessed with multiple systematic reviews with meta-analyses demonstrating that while there may be an increased risk of acute pancreatitis with the DPP-4 inhibitors, there is no clear association with GLP1-RAs 16

Key Points Summary Thyroid and Metabolism: The thyroid regulates metabolism via T4 and T3 hormones, essential for energy (ATP) production