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ZhaoLWangCSongDLiYSongYSuGet alSystemic administration of the antioxidant/iron chelator alpha-lipoic acid protects against light-induced photoreceptor degeneration in the mouse retina
Technical Specifications: Synonyms: Long R Insulin-like Growth Factor 1
This reaction limits the synthesis of PE-AA, reducing the concentration of lipid peroxides and peroxy radicals, thereby conferring resistance to ferroptosis
For example, exogenous iron (such as ferric ammonium citrate and ferric citrate) supplementation, increased iron uptake (such as TFR1 overexpression), decreased iron storage (such as ferritin knockdown) and impaired iron efflux (such as FPN1 knockdown) contribute to iron overload and enhance the sensitivity to ferroptosis (19,20)
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