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By blocking NNMT, it prevents the methylation reaction that depletes SAM and nicotinamide, thereby preserving both cofactors and restoring the metabolic machinery that NNMT overexpression had suppressed

But for many sufferers, the problem stems from an underlying vitamin B12 deficiency

Skin & Systemic Effects Improved metabolic efficiency and reduced oxidative stress may contribute to better skin tone, clarity, and overall tissue quality, reflecting enhanced cellular function rather than direct cosmetic action

We can't jump from personal experiences to assuming that some biological process is not working when we don't yet even have a good idea of how that process would work in a healthy person yet