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Moreover, necroptosis-related lncRNAs, such as LINC00472, which regulates RIPK1, have demonstrated their predictive value for the prognosis of patients with breast cancer and their guiding value for personalised treatment strategies [63]

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However, translational attempts of mTOR inhibition have been unsuccessful in ameliorating cognitive functioning, behavioral problems, autism and neuropsychological deficits in children ages 4-17 treated with Everolimusanother mTOR inhibitor that was previously FDA approved for cancer treatments [120]