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thus, it may induce hypoglycemia and it is contraindicated in patients with advanced liver insufficiency.66 In contrast, the pharmacodynamics of nateglinide is not altered in patients with CLD and is thus expected to be safer.67 Incretin-based therapies Incretin-based therapies comprise injectable glucagon-like peptide-1 (GLP-1) receptor agonists and oral inhibitors of dipeptidylpeptidase-4 (DPP-4)(gliptins)