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(d) RT-qPCR reduction assay testing activity of AtNUDX23 and Rpp against in vitro transcribed FAD-capped RNA (left) and showing the lack of activity of the AtNUDX23-E169Q protein (right)

The report lists each toxin on the panel and indicates if it was detected, along with the numeric level

Known risks and side effects: Increased appetite, commonly reported and documented at a substantially higher rate on MK-677 than placebo (67% versus 36% of participants) in the Nass et al

Our identification of VRK2-mediated SLC7A11 trafficking suggests a potential immune evasion mechanism, as SLC7A11-high tumors often display T cell exclusion phenotypes [37], warranting future investigation into whether VRK2 expression could predict therapeutic response to combined ferroptosis inducers and immune checkpoint inhibitors