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A 2015 systematic review and meta-analysis of 8 randomised trials found that NAC produced higher pregnancy rates than placebo across the placebo-comparison subgroup (pregnancy odds ratio 3.97, 95% CI 2.077.59), though in the same analysis NAC was less effective than metformin for pregnancy outcomes (OR 0.40, 95% CI 0.230.71)

The GPX4/GSH axis is a central regulator of ferroptosis, a form of regulated cell death (RCD) that is closely associated with lipid peroxidation

This can lead to an increase in blood flow to the brain, which can cause a temporary increase in intracranial pressure and result in a headache