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By mediating the transcription of crucial antioxidative enzymes, FOXO4 may help mitigate oxidative stress and maintain cellular integrity and function during episodes of high oxidative load or inflammation

Non-12-OH FXR-antagonistic BAs mediates the T3 effect on glucose homeostasis To dissect the contribution of the augmentation of non-12-OH FXR-antagonistic BAs to the improved glucose metabolism after T3 daily injection, MMI mice were fed a diet supplemented with TMCA, the most abundant murine FXR-antagonistic BA, for five days

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