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In addition, the presence of multiple comorbidities increases the likelihood of drug-drug interactions and limits the patients physiologic reserve, rendering them more susceptible to cumulative toxicity, fatigue, and myelosuppression

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Moreover, the use of ferroptosis inhibitors increases the sensitivity of these osteosarcoma cells to cisplatin, while diminishing the levels of ferroptosis-related proteins further enhances this sensitivity (191)

25 , e400e407 (2015)