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Despite these challenges, semaglutide has the enormous practical advantage of being an approved, regulated pharmaceutical product

Synthetic GLP-1 drugs each have their own modification that allows them to slip by DPP-4 or survive longer in the blood

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Most common adverse reactions for Wegovy (semaglutide) The most common adverse reactions for Wegovy (incidence 5%) are nausea, diarrhea, vomiting, constipation, abdominal pain, dysesthesia, headache, fatigue, dyspepsia, dizziness, abdominal distension, eructation, hypoglycemia in patients with type 2 diabetes, flatulence, gastroenteritis, gastroesophageal reflux disease, and hair loss