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In addition to the ominous octet, further pathways contributing to hyperglycemia have been delineated, which include systemic low-grade inflammation [6, 7], changes in gut microbiota [8, 9], and reductions in amylin production [10]

Nighttime leg cramps, often called charley horses, are common when the body is dehydrated or lacking minerals like magnesium and potassium

Nausea typically occurs during the first 4-8 weeks of treatment or following dose increases, with many patients experiencing gradual improvement as their body adjusts to the medication

However, the majority of research has been conducted in animals, and more comprehensive human studies are needed to establish its long-term safety