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Thus, in addition to a comprehensive approach encompassing multidisciplinary risk factors (dyslipidaemia, hypertension, obesity, smoking, etc.) [8, 9], considering "what drugs to use to lower blood glucose" by selecting hypoglycaemic agents with evidence-based cardiorenal protective effects, according to patient background and risk status is increasingly important [10]

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Additionally, Seki and colleagues reported that neuropeptide Y (NPY), a potent orexigenic peptide, directly acts on MTNs