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The Science of Safety: Adverse Effects of GLP-1 Receptor Agonists as Glucose-Lowering and Obesity Medications

A significant issue, however, is just the moderate concordance between differing methodologies, [22] which is likely indicative of the tests reflecting different pathologies [23], and thus they should be considered as complementary rather than equivalent [14]

The study found no significant differences in systemic side effects between routes, but noted that injection site reactions were the leading cause of treatment discontinuation (3% of injectable users versus 1% of oral users discontinuing due to GI upset)

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