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Geographic disparities are evident, with low- and middle-income countries facing amplified risks due to infrastructure and regulatory gaps

Progressive depletion of cellular glutathione is also used as a mechanism by many viruses to control their replication cycle during infection

Moreover, the way GSH depletion can lead to immune system failure and make the end organs in danger of oxidative stress-mediated damage needs to be explained

The immune response to this damage, characterized by M1 macrophage polarization, neutrophilic inflammation, and Th17 activation, further exacerbates lipid peroxidation and ferroptosis, creating a vicious cycle that drives disease progression