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It has long been used in oncology and specific folate-related conditions
However, it is important to note that apoptotic cells can release DAMPs even in the absence of critical plasma membrane perturbations, in particular, via secretory lysosomes or exosomes [234, 235]
Ebrahimi R, Sepand MR, Seyednejad SA, Omidi A, Akbariani M, Gholami M, et al Ellagic acid reduces methotrexate-induced apoptosis and mitochondrial dysfunction via up-regulating Nrf2 expression and inhibiting the IB/NFB in rats Daru
The local GI concentration achieved orally may actually be an advantage for gut-specific applications
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