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Merkel et al., 2025)

In the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) [17] trial, the Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diabetes (SUSTAIN-6) [18], the Harmony Outcomes [19] trial and the AMPLITUDE-O [20] trial, individuals with type 2 diabetes and at high risk of CVD (81100% with established CVD) were randomly assigned to receive either GLP-1RA or placebo

One idea is a do-it-yourself face-massage

Please note that compounded medications are not the same as commercially manufactured, brand-name pharmaceuticals produced by large pharmaceutical companies