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Importantly, AOD-9604 did not produce any of the adverse effects associated with growth hormone therapy, including glucose intolerance, insulin resistance, edema, joint pain, or tissue growth abnormalities

GLP-1 Receptor Agonists Published April 1, 2026 N Engl J Med 2026;394:1313-1324 DOI: 10.1056/NEJMra2500106 Summary Glucagon-like peptide-1 (GLP-1) receptor agonists are incretin analogues that promote glucose-mediated insulin release and are used to treat type 2 diabetes mellitus and obesity

Sleep and well-being often improve within weeks, while cellular longevity benefits build gradually over time