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Available from: Zarrinkoub R, Wettermark B, Wndell P, Mejhert M, Szulkin R, Ljunggren G et al (2013) The epidemiology of heart failure, based on data for 2.1 million inhabitants in Sweden

Industry case studies (beyond Roche) include: Siemens and digital pharma: Siemens has published about using twins from lab R&D to manufacturing, pointing out that Pharma 4.0 (the intelligent factory) uses twins to realize end-to-end digitalization ( [30] )

Although the results of these studies support the hypothesis that the quality of dietary intake is altered for patients on GLP-1 or GIP/GLP-1 RAs, they did not objectively measure dietary intake so these, as well as similar studies evaluating appetite perception, were not included in this review

For peripheral vascular disease, where reduced blood flow to the extremities causes pain and tissue damage, this collateral activation mechanism could theoretically provide meaningful benefit