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Sources and Scientific References U.S

doi:10.1016/j.biopha.2020.110137

Hohenfellner K, Rauch F, Ariceta G, Awan A, Bacchetta J, Bergmann C, Bechtold S, Cassidy N, Deschenes G, Elenberg E, Gahl WA, Greil O, Harms E, Herzig N, Hoppe B, Koeppl C, Lewis MA, Levtchenko E, Nesterova G, Santos F, Schlingmann KP, Servais A, Soliman NA, Steidle G, Sweeney C, Treikauskas U, Topaloglu R, Tsygin A, Veys K, R VV, Zustin J, Haffner D (2019) Management of bone disease in cystinosis: statement from an international conference

Such changes are associated with impaired epithelial integrity, enhanced LPS-mediated immune activation, and downstream systemic and central inflammatory processes linked to dopaminergic neurodegeneration