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Over the course of 40 weeks, TZP exhibited a remarkable average increase of 97-120% in HOMA2-B, calculated with C-peptide, compared to 84% with SEMA
00:07:00 Vickie Danaher But injectable tirzepatide or Zepbound achieves more, about 41 pounds more weight loss than placebo over a year in patients without diabetes
it needs its own treatment
To mitigate this, clinicians may consider prescribing: Transdermal oestrogen Alongside a non-oral progestogen (e.g., micronised progesterone or an intrauterine system), especially in patients on GLP-1 receptor agonists or GIP/GLP-1 dual agonists like tirzepatide
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