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A second possibility is the manipulation of dopamine catabolism, as SIV infection increases the expression and activity of MAO-B in the CNS, which correlates with increases in oxidative stress, disease severity, neuroinflammation, and levels of the myeloid cell marker CD68

Ethics declarations Ethics approval and consent to participate The study protocol was approved by the ethics committee of Guilan University of Medical Sciences (IR.GUMS.REC.1400.197) in accordance with the World Medical Associations code of ethics (Declaration of Helsinki, revised in Brazil 2013), and registered at an ICMJE and WHO recognized registry of clinical trials (www.irct.ir) at 28/08/2021 (registration number: IRCT20200920048782N1)

In terms of expectations, it is important to recognize that Gelatine Sculpt is not a magic bullet

These scenarios are not broadly applicable, but they represent cases where the risk-benefit calculation might favor cycling