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Increasing ATP availability, reducing reactive oxygen species (ROS) generation by mitochondrial complex I, inhibiting the mitochondrial permeability transition pore, and stimulating mitochondrial biogenesis, all seem to stabilize synaptic functions

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Yet, after over a century of research, the penultimate biosynthetic step to anthocyanidins attributed to the action of leucoanthocyanidin dioxygenase has never been efficiently reconstituted outside plants, preventing the construction of heterologous cell factories

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