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For 1 H- 15 N heteronuclear single quantum coherence (HSQC) titration experiments, the concentration of p53 TAD PEP was increased while maintaining the same ratio of 14 N-FOXO4 FHD and 15 N labeled-p53 TAD

Part of the reason is that anti-TNF agents block one specific cytokine while leaving the rest of the inflammatory network intact

All tumours were iso/hypointense both on T1- and T2-weighted MRI, and showed marked contrast enhancement in their non-ossified components

These drugs were originally developed to treat type 2 diabetes, and worked by mimicking the natural hormones that lower blood sugar levels and slow down digestion